Hypereosinophilic Syndrome: A Case of Diagnostic and Therapeutic Difficulty

Hypereosinophilic syndrome (HES) is a condition with diverse clinical presentation and prognosis. Due to its rarity, it often under-recognized. We present 48-year-old female patient who presented eosinophilic pneumonia bullous pemphigoid; rare skin manifestation of HES. It was considered as primary HES after comprehensive evaluation excluded secondary causes. However, picture laboratory makers were inconclusive categorize her either myeloid or lymphoid presumed be Lymphoid subtype since she responded well course cyclosporin A. heterogeneous multiple molecular markers, eosinophilia may challenging, time consuming costly. Expanding knowledge disease endotyping novel biomarkers have favorably modified the diagnosis management